Differential contributions of cardiac, coronary and pulmonary artery vagal mechanoreceptors to reflex control of the circulation

JP Moore, LL Simpson… - The Journal of physiology, 2022 - Wiley Online Library
Distinct populations of stretch‐sensitive mechanoreceptors attached to myelinated vagal
afferents are found in the heart and adjoining coronary and pulmonary circulations …

The effect of hypoxemia on muscle sympathetic nerve activity and cardiovascular function: a systematic review and meta-analysis

MM Tymko, D Young, D Vergel… - American Journal …, 2023 - journals.physiology.org
We conducted a systematic review and meta-analysis to determine the effect of acute
poikilocapnic, high-altitude, and acute isocapnia hypoxemia on muscle sympathetic nerve …

Highs and lows of sympathetic neurocardiovascular transduction: influence of altitude acclimatization and adaptation

LF Berthelsen, GM Fraser… - American Journal …, 2020 - journals.physiology.org
High-altitude (> 2,500 m) exposure results in increased muscle sympathetic nervous activity
(MSNA) in acclimatizing lowlanders. However, little is known about how altitude affects …

A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies

LL Simpson, CD Steinback… - Experimental …, 2021 - Wiley Online Library
New Findings What is the topic of the review? Sympathoexcitation and sympathetic control
of blood pressure at high altitude. What advances does it highlight? Sustained …

Mechanisms underpinning sympathoexcitation in hypoxia

LL Simpson, M Stembridge… - The Journal of …, 2024 - Wiley Online Library
Sympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as
persisting in acclimatised lowland populations and with generational exposure in highland …

Global REACH 2018: Andean highlanders, chronic mountain sickness and the integrative regulation of resting blood pressure

LL Simpson, VL Meah, AR Steele… - Experimental …, 2021 - Wiley Online Library
New Findings What is the central question of this study? Does chronic mountain sickness
(CMS) alter sympathetic neural control and arterial baroreflex regulation of blood pressure in …

Evaluating Total Atherosclerosis Burden of Baroreceptor-Resident Arteries after Ischemic Cerebrovascular Disease for Identifying Patients with Heavy Coronary …

Q Kong, X Ma, L Li, C Wang, X Du… - Journal of Atherosclerosis …, 2024 - jstage.jst.go.jp
Aim: The carotid sinuses and aortic arch are baroreceptor-resident arteries (BRAs) and
atherosclerosis-susceptible sites of brain-supplying arteries, which would impair baroreflex …

Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males

LL Simpson, AB Hansen, G Moralez… - American Journal …, 2023 - journals.physiology.org
Sympathetic transduction is reduced following chronic high-altitude (HA) exposure;
however, vascular α-adrenergic signaling, the primary mechanism mediating sympathetic …

Global REACH 2018: renal oxygen delivery is maintained during early acclimatization to 4,330 m

AR Steele, MM Tymko, VL Meah… - American Journal …, 2020 - journals.physiology.org
Early acclimatization to high altitude is characterized by various respiratory, hematological,
and cardiovascular adaptations that serve to restore oxygen delivery to tissue. However …

Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude

P Subedi, C Gasho, M Stembridge… - Experimental …, 2023 - Wiley Online Library
Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the
time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being …