Animal experimentation helps us to understand human biology. Rodents and, in particular,
rats are among the most common animals used in animal experiments. Reporting data on …

Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …

Aging causes changes in the hippocampus that may lead to cognitive decline in older
adults. In young animals, exercise increases hippocampal neurogenesis and improves …

Before the 1990s it was widely believed that the adult brain was incapable of regenerating
neurons. However, it is now established that new neurons are continuously produced in the …

New neurons are generated in the adult hippocampus throughout life by neural
stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external …

Emerging data indicate that progesterone has multiple non-reproductive functions in the
central nervous system to regulate cognition, mood, inflammation, mitochondrial function …

In this review, we consider the evidence that a reduction in neurogenesis underlies aging-
related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD) …

The capability of the mammalian brain to generate new neurons through the lifespan has
gained much attention for the promise of new therapeutic possibilities especially for the …

This article is part of a Special Issue “Estradiol and Cognition”. There are sex differences in
hippocampus-dependent cognition and neurogenesis suggesting that sex hormones are …

Strong age-related declines in conjunction with comparatively easy experimental
manipulations of adult hippocampal neurogenesis have generated considerable public and …