The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Microglia are the primary immune cells of the CNS, carrying out key homeostatic roles and
undergoing context-dependent and temporally regulated changes in response to injury and …

Overweight and obesity are now considered a worldwide pandemic and a growing public
health problem with severe economic and social consequences. Adipose tissue is an organ …

GGGGCC repeat expansion in C9ORF72, which can be translated in both sense and
antisense directions into five dipeptide repeat (DPR) proteins, including poly (GP), poly …

Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein
TDP-43 are found in~ 90% of cases of amyotrophic lateral sclerosis and~ 45% of patients …

The current treatments for neurodegenerative diseases are mostly symptomatic without
affecting the underlying cause of disease. Emerging evidence supports a potential role for …

The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal
dementia, but the poor correlation between C9orf72‐specific pathology and TDP‐43 …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease, which is characterized by
the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently …

The most common inherited cause of two genetically and clinico-pathologically overlapping
neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive
loss of motor neurons, leading to a fatal paralysis. According to whether there is a family …