Pancreatic cancer
Substantial progress has been made in our understanding of the biology of pancreatic
cancer, and advances in patients' management have also taken place. Evidence is …
cancer, and advances in patients' management have also taken place. Evidence is …
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil
H Hirai, T Arai, M Okada, T Nishibata… - Cancer biology & …, 2010 - Taylor & Francis
MK-1775 is a potent and selective small molecule Wee1 inhibitor. Previously we have
shown that it abrogated DNA damaged checkpoints induced by gemcitabine, carboplatin …
shown that it abrogated DNA damaged checkpoints induced by gemcitabine, carboplatin …
miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase …
V Boni, N Bitarte, I Cristobal, R Zarate… - Molecular cancer …, 2010 - AACR
Thymidylate synthase (TYMS) is a target of the most widely used chemotherapeutic agents
against gastrointestinal malignancies, the fluoropyrimidine-based therapy. TYMS expression …
against gastrointestinal malignancies, the fluoropyrimidine-based therapy. TYMS expression …
PharmGKB summary: fluoropyrimidine pathways
CF Thorn, S Marsh, MW Carrillo… - Pharmacogenetics …, 2011 - journals.lww.com
Fluoropyrimidines are antimetabolite drugs widely used in the treatment of solid tumors
including colorectal cancer, breast cancer, and cancers of the aerodigestive tract [1–3] …
including colorectal cancer, breast cancer, and cancers of the aerodigestive tract [1–3] …
Prognostic significance of miR-215 in colon cancer
M Karaayvaz, T Pal, B Song, C Zhang… - Clinical colorectal …, 2011 - Elsevier
Background We have previously shown that miR-215 suppressed the expression of key
targets such as thymidylate synthase (TS), dihydrofolate reductase, and denticleless protein …
targets such as thymidylate synthase (TS), dihydrofolate reductase, and denticleless protein …
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP [10] with fluorouracil, floxuridine, and topoisomerase 1 poisons
A profile of microRNA (miRNA) and mRNA expression patterns across the NCI-60 cell-line
screen was analyzed to identify expression signatures that correlate with sensitivity to …
screen was analyzed to identify expression signatures that correlate with sensitivity to …
Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer
Z Heger, MA Merlos Rodrigo, P Michalek, H Polanska… - Plos one, 2016 - journals.plos.org
The effects of sarcosine on the processes driving prostate cancer (PCa) development
remain still unclear. Herein, we show that a supplementation of metastatic PCa cells …
remain still unclear. Herein, we show that a supplementation of metastatic PCa cells …
[HTML][HTML] Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer
C Burdelski, C Strauss, MC Tsourlakis, M Kluth… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Thymidylate synthase (TYMS) plays a role in DNA synthesis and is a target for 5-fluorouracil.
In this study TYMS was analyzed by immunohistochemistry on a tissue microarray …
In this study TYMS was analyzed by immunohistochemistry on a tissue microarray …
dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial
Deoxycytidine kinase (dCK) and human antigen R (HuR) have been associated with
response to gemcitabine in small studies. The present study investigates the prognostic and …
response to gemcitabine in small studies. The present study investigates the prognostic and …
Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells
T Samuel, K Fadlalla, L Mosley, V Katkoori… - Anticancer …, 2012 - ar.iiarjournals.org
Background: DNA-damaging drugs constitute standard chemotherapy regimen for advanced
colorectal cancer. Here, the interactions between quercetin and 5-fluorouracil (5-FU) …
colorectal cancer. Here, the interactions between quercetin and 5-fluorouracil (5-FU) …