Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state
A classic view of the striatum holds that activity in direct and indirect pathways oppositely
modulates motor output. Whether this involves direct control of movement, or reflects a …
modulates motor output. Whether this involves direct control of movement, or reflects a …
[HTML][HTML] Brain-wide neural activity underlying memory-guided movement
Behavior relies on activity in structured neural circuits that are distributed across the brain,
but most experiments probe neurons in a single area at a time. Using multiple Neuropixels …
but most experiments probe neurons in a single area at a time. Using multiple Neuropixels …
Superior colliculus bidirectionally modulates choice activity in frontal cortex
Action selection occurs through competition between potential choice options. Neural
correlates of choice competition are observed across frontal cortex and downstream …
correlates of choice competition are observed across frontal cortex and downstream …
Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia
E Wärnberg, A Kumar - Proceedings of the National …, 2023 - National Acad Sciences
It is well established that midbrain dopaminergic neurons support reinforcement learning
(RL) in the basal ganglia by transmitting a reward prediction error (RPE) to the striatum. In …
(RL) in the basal ganglia by transmitting a reward prediction error (RPE) to the striatum. In …
The secondary motor cortex-striatum circuit contributes to suppressing inappropriate responses in perceptual decision behavior
J Liu, D Liu, X Pu, K Zou, T Xie, Y Li, H Yao - Neuroscience bulletin, 2023 - Springer
The secondary motor cortex (M2) encodes choice-related information and plays an
important role in cue-guided actions. M2 neurons innervate the dorsal striatum (DS), which …
important role in cue-guided actions. M2 neurons innervate the dorsal striatum (DS), which …
[HTML][HTML] Superior colliculus cell types bidirectionally modulate choice activity in frontal cortex
Action selection occurs through competition between potential choice options. Neural
correlates of choice competition are observed across frontal cortex and downstream …
correlates of choice competition are observed across frontal cortex and downstream …
The frontal cortex adjusts striatal integrator dynamics for flexible motor timing
Flexible control of motor timing is crucial for behavior. Before movement begins, the frontal
cortex and striatum exhibit ramping spiking activity, with variable ramp slopes anticipating …
cortex and striatum exhibit ramping spiking activity, with variable ramp slopes anticipating …
A blueprint for examining striatal control of cognition
EN Holly, E Díaz-Hernández, MV Fuccillo - Trends in neurosciences, 2022 - cell.com
In a recent study, Bolkan, Stone, and colleagues demonstrated that direct and indirect
striatal pathways in mice exert opponent control over choice behavior in a task-and state …
striatal pathways in mice exert opponent control over choice behavior in a task-and state …
Vector-valued dopamine improves learning of continuous outputs in the striatum
E Wärnberg, A Kumar - bioRxiv, 2022 - biorxiv.org
It is well established that midbrain dopaminergic neurons support reinforcement learning
(RL) in the basal ganglia by transmitting a reward prediction error (RPE) to the striatum. In …
(RL) in the basal ganglia by transmitting a reward prediction error (RPE) to the striatum. In …