2H/4H-Chromenes—A versatile biologically attractive Scaffold

V Raj, J Lee - Frontiers in Chemistry, 2020 - frontiersin.org
2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile
biological profiles, a simple structure, and mild adverse effects. Researchers discovered …

Fused and substituted pyrimidine derivatives as profound anti-cancer agents

N Abbas, GSP Matada, PS Dhiwar… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
The rationale behind drug design is the strategic utilization of heterocyclic fragments with
specific physicochemical properties to form molecular targeted agents. Among the …

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P …

LM Al-Harbi, EA Al-Harbi, RM Okasha… - Journal of enzyme …, 2023 - Taylor & Francis
A series of 1 H-benzo [f] chromene moieties (4a–z) were synthesised under Ultrasonic
irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray …

Discovery of pyran annulated heterocyclic scaffolds linked to carboxamide fragments: Anticancer evaluation, topoisomerase I/II, tyrosine kinase receptor inhibition and …

AM Fouda, RA El-Eisawy, MAA El-Nassag… - Journal of Molecular …, 2024 - Elsevier
A class of 4H-benzo [h] chromene (4a-h) and 1H-benzo [f] chromene (6a-h) derivatives
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …

Synthesis, Cytotoxic Activity, Crystal Structure, DFT Studies and Molecular Docking of 3-Amino-1-(2,5-dichlorophenyl)-8-methoxy-1H-benzo[f]chromene-2 …

M El Gaafary, T Syrovets, H M. Mohamed… - Crystals, 2021 - mdpi.com
The target compound 3-amino-1-(2, 5-d ichlorophenyl)-8-methoxy-1 H-benzo [f]-chromene-2-
carbonitrile (4) was synthesized via a reaction of 6-methoxynaphthalen-2-ol (1), 2, 5 …

Synthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II …

AH Halawa, WE Elgammal, SM Hassan, AH Hassan… - Bioorganic …, 2020 - Elsevier
A series of heterocyclic compounds with a sulfonamide moiety were synthesized from
reaction of enaminone 4 with active methylene compounds, glycine derivatives, 1, 4 …

Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by …

AKB Aljohani, WAZ El Zaloa, M Alswah… - International journal of …, 2023 - mdpi.com
Phenylpyrazolo [3, 4-d] pyrimidine is considered a milestone scaffold known to possess
various biological activities such as antiparasitic, antifungal, antimicrobial, and …

First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone …

RM Okasha, M Alsehli, S Ihmaid, SS Althagfan… - Bioorganic …, 2019 - Elsevier
This report presents the development of a novel and primary model of sulfonamide
compounds encompassing a chromene azo motif with the intent of becoming applicable for …

In vitro anticancer activity of pyrano[3, 2-c]chromene derivatives with both cell cycle arrest and apoptosis induction

AM El-Agrody, AM Fouda, MA Assiri, A Mora… - Medicinal Chemistry …, 2020 - Springer
Abstract A series of 2-amino-4-aryl-5-oxo-4, 5-dihydropyrano [3, 2-c] chromene-3-
carbonitrile (4a–m) were synthesized via a one-pot three component condensation reaction …

[HTML][HTML] Synthesis, evaluation of the cytotoxicity, apoptosis induction in AGS cell line and gene expression and molecular modeling studies of novel …

S Sepehri, Y Panahi, D Abbasi, M Jafari… - Arabian Journal of …, 2024 - Elsevier
Cancer is a complex disease that remains a leading cause of death worldwide owing to the
lack of effective and efficient drugs. Compounds known as tetrahydropyrmidine have shown …