Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

Long noncoding RNAs (lncRNAs) affect gene regulation through structural and regulatory
interactions with associated proteins. The Polycomb complex often binds to lncRNAs in …

Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …

Histone modifications are key components of chromatin packaging but whether they
constitute a 'code'has been contested. We believe that the central issue is causality: are …

In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …

Chromatin accessibility plays a fundamental role in gene regulation. Nucleosome
placement, usually measured by quantifying protection of DNA from enzymatic digestion …

Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable
transcriptional silencing. PcG proteins participate in distinct multimeric complexes that …

During growth of multicellular organisms, identities of stem cells and differentiated cells
need to be maintained. Cell fate is epigenetically controlled by the conserved Polycomb …