The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

There is an enormous global public health burden due to antimicrobial-resistant (AMR)
Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

Abstract Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of
hospital-and community-acquired infections, including sepsis, liver abscess, and …

Objectives Recent reports indicate the emergence of a new carbapenemase-producing
Klebsiella pneumoniae clone, ST307. We sought to better understand the global …

Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …

Colistin is widely used in food-animal production. Salmonella enterica is a zoonotic
pathogen, which can pass from animal to human microbiota through the consumption of …

Polymyxins, especially polymyxin B and polymyxin E (colistin), are considered to be the last
line of defence against infections caused by multi-drug-resistant (MDR) gram-negative …

Klebsiella pneumoniae sequence type (ST) 307 is an emerging global antimicrobial drug–
resistant clone. We used whole-genome sequencing and PCR to characterize K …

abstract This systematic review focuses on obtaining the most relevant information from
multiple studies that detected a mobilized colistin resistance mcr gene in Salmonella for a …