The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to
seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is …

In the physiological condition, the skeletal system's bone resorption and formation are in
dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under …

Extracellular vesicles (EVs), which can be found in almost all body fluids, consist of a lipid
bilayer enclosing proteins and nucleic acids from their cells of origin. EVs can transport their …

Exosomes mediate cell-cell crosstalk in cancer progression by transferring their molecular
cargos, including long noncoding RNAs (lncRNAs). Metastasis‑associated lung …

Repair of critical-size bone defects in patients with diabetes mellitus (DM) has always been
a challenge in clinical treatment. The process of bone defect regeneration can be impaired …

In recent years, it has been demonstrated that extracellular vesicles (EVs) can be released
by almost all cell types, and detected in most body fluids. In the tumour microenvironment …

Long noncoding (lnc) RNAs are a group of RNAs with a length greater than 200 nt that do
not encode a protein but play an essential role in regulating the expression of target genes …

Approximately 98% of the human genome consists of non-coding sequences that are
classified into two classes by size: small non-coding RNAs (≤ 200 nucleotides) and long …

The present study aims to analyze the expression of long noncoding RNA (lncRNA)
metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in human osteosarcoma …

Angiogenesis is an essential step in maintaining tumor growth and facilitating metastasis.
The regulatory mechanisms of tumor-induced angiogenesis are extremely complicated, and …