Social rewards are strong drivers of behavior and fundamental to well-being, yet there is a
lack of consensus regarding what actually defines a reward as “social.” Because a …

Delusions are rigid beliefs held with high certainty despite contradictory evidence.
Notwithstanding decades of research, we still have a limited understanding of the …

BackgroundReward dysfunction is a major dimension of depressive symptomatology, but it
remains obscure if that dysfunction varies across different reward types. In this study, we …

Sex is a significant source of heterogeneity in schizophrenia, with more negative symptoms
in males and more affective symptoms and internalizing comorbidity in females. In this …

Background Deficient social interactions are a hallmark of major neuropsychiatric disorders,
and accumulating evidence points to altered social reward and motivation as key underlying …

Neurexins are presynaptic transmembrane proteins crucial for synapse development and
organization. Deletion and missense mutations in all three Neurexin genes have been …

As a part of a larger Affectome Project (http://neuroqualia. org/background. php) with an
overarching goal of mapping and redefining biological substrates of feelings and emotions …

Abstract Background and Hypothesis Social motivation, defined as the fundamental human
desire to seek out, engage in, and maintain interpersonal bonds, has become a growing …

Anhedonia has long been considered a cardinal symptom of schizophrenia. This symptom is
strongly associated with poor functional outcome, and limited treatment options are …

Abstract Internet Gaming Disorder (IGD) is a behavioural addiction characterised by
excessive exposure to addictive stimuli, resulting in reduced sensitivity of the brain's reward …