Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo [2, 1-b][1, 3, 4] thiadiazoles as highly potent acetylcholinesterase and non …
Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
Recent developments in the cyclization of alkynes and nitrogen compounds for the synthesis of indole derivatives
JSS Neto, G Zeni - Asian Journal of Organic Chemistry, 2021 - Wiley Online Library
This review is intended to highlight the most useful approaches for the synthesis of indole
derivatives (azaindoles, carbazoles, carbolines, indazoles, 3H‐indoles, indolines …
derivatives (azaindoles, carbazoles, carbolines, indazoles, 3H‐indoles, indolines …
Computational studies applied to flavonoids against Alzheimer's and Parkinson's diseases
AFM Monteiro, JDO Viana, A Nayarisseri… - Oxidative medicine …, 2018 - Wiley Online Library
Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as
occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several …
occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several …
Insights into synthesis, reactivity, and biological activity of N-isoindoline-1, 3-diones heterocycles: a systematic literature review
This review paper provides a comprehensive overview of recent advancements in the
synthesis, reactivity, and applications of N-isoindoline-1, 3-dione heterocycles. These …
synthesis, reactivity, and applications of N-isoindoline-1, 3-dione heterocycles. These …
Identification and evaluation of boronic compounds ameliorating cognitive deficit in orchiectomized rats
ED Farfán-García, MC Rosales-Hernández… - Journal of Trace …, 2022 - Elsevier
Background Boron is a trace element with increasing importance in drug design. In this
sense, boronic acids are emerging as therapeutic agents for several diseases. Methods …
sense, boronic acids are emerging as therapeutic agents for several diseases. Methods …
Synthesis, in silico, and evaluation of AChE inhibitory activity of N-phthaloylphenylglycine derivatives as potential anti-Alzheimer's agents
E Andrade-Jorge, N Reyes-Vallejo… - Medicinal Chemistry …, 2023 - Springer
Mental illnesses are one of the most relevant health problems today, among which
Alzheimer's disease (AD) stands out. This is a severe disease that entails different …
Alzheimer's disease (AD) stands out. This is a severe disease that entails different …
Synthesis, molecular modeling and cholinesterase inhibitory effects of 2-indolinone-based hydrazinecarbothioamides
Background: 2-Indolinone-based hydrazinecarbothioamides carrying a 3-
phenylsulfonamide moiety (7–9) were designed by replacement of donepezil's …
phenylsulfonamide moiety (7–9) were designed by replacement of donepezil's …
Synthesis and biological evaluation of 1, 2, 4-triazolidine-3-thiones as potent acetylcholinesterase inhibitors: in vitro and in silico analysis through kinetics …
We have designed and synthesized a novel acidic ionic liquid and explored its catalytic
efficiency for the synthesis of 1, 2, 4-triazolidine-3-thione derivatives. A simple reaction …
efficiency for the synthesis of 1, 2, 4-triazolidine-3-thione derivatives. A simple reaction …
Biomimetic synthesis of galantamine via laccase/TEMPO mediated oxidative coupling
Laccase-mediated intramolecular oxidative radical coupling of N-formyl-2-bromo-O-
methylnorbelladine afforded a novel and isolable spirocyclohexadienonic intermediate of …
methylnorbelladine afforded a novel and isolable spirocyclohexadienonic intermediate of …
Isoindolone derivatives as novel potential anti-Alzheimer's candidates: synthesis, in silico, and AChE inhibitory activity evaluation
E Andrade-Jorge, F Rivera-Sanchez… - Medicinal Chemistry …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative condition that affects elderly persons
around the world, impairing cognitive function, due to a decrease in cholinergic …
around the world, impairing cognitive function, due to a decrease in cholinergic …