The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-
organisms and the digestive tract highly contribute to maintain the gut homeostasis …

Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

INTRODUCTION Members of the human gut microbiota have been implicated in the
development and progression of colorectal cancer (CRC). These CRC-associated …

INTRODUCTION Research on the human microbiome has revealed extensive correlations
between bacterial populations and host physiology and disease states. However, moving …

Inflammation and microbiota are critical components of intestinal tumorigenesis. To dissect
how the microbiota contributes to tumor distribution, we generated germ-free (GF) ApcMin/+ …

Covering: up to 2013 Although holo-acyl carrier protein synthase, AcpS, a
phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until …

Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new
cyclomodulin called colibactin, which is synthetized by the pks genomic island, was …

Members of the human microbiota are increasingly being correlated to human health and
disease states, but the majority of the underlying microbial metabolites that regulate host …

Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli,
Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island …

Colibactin is a chemically unstable small-molecule genotoxin that is produced by several
different bacteria, including members of the human gut microbiome,. Although the biological …