Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

▪ Abstract Organisms are exposed to epoxide-containing compounds from both exogenous
and endogenous sources. In mammals, the hydration of these compounds by various …

The precise mechanistic relationship between gene activation and repression events is a
central question in mammalian organogenesis, as exemplified by the evolutionarily …

Adaptation to seasonal change is a crucial component of an organism's survival strategy. To
monitor seasonal variation, organisms have developed the capacity to measure day length …

Amino Acid Metabolism, 3rd Edition covers all aspects of the biochemistry and nutritional
biochemistry of the amino acids. Starting with an overview of nitrogen fixation and the …

Abstract The sarcoplasmic reticulum Ca2+-ATPase, a P-type ATPase, has a critical role in
muscle function and metabolism. Here we present functional studies and three new crystal …

Serine is generally classified as a nutritionally nonessential (dispensable) amino acid, but
metabolically, serine is indispensible and plays an essential role in several cellular …

Cofilin is a key regulator of actin cytoskeletal dynamics whose activity is controlled by
phosphorylation of a single serine residue. We report the biochemical isolation of …

Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of
phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP …

Post-translational modifications provide sensitive and flexible mechanisms to dynamically
modulate protein function in response to specific signalling inputs. In the case of …