Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …

Chemotherapy is one of the most established and effective treatments for almost all types of
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …

Colorectal cancer (CRC) is one of the major health threats in developed countries. Changes
in dietary components, such as more protein and lipid intake, can increase the risk of CRC …

Epigenetic mechanisms play a crucial role in regulating gene expression. The main
mechanisms involve methylation of DNA and covalent modifications of histones by …

Abstract Among different Histone deacetylases (HDACs), histone deacetylase 3 (HDAC3) is
an epigenetic drug target which is currently marked as a potential therapeutic strategy to …

In the last two decades vitamin D (VD) research has demonstrated new extraskeletal actions
of this pre-hormone, suggesting a protective role of this secosteroid in the onset, progression …

Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Studies over the past four decades have elucidated the role of Wnt/β-catenin mediated
regulation in cell proliferation, differentiation and migration. These processes are …

Epidemiologic data suggest that the incidence and severity of many types of cancer
inversely correlates with indices of vitamin D status. The vitamin D receptor (VDR) is highly …

An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of
stereochemically and skeletally diverse small molecules. In the build phase, a series of …