Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …

Physical exercise promotes cardiorespiratory fitness, and is considered the mainstream of
non-pharmacological therapies along with lifestyle modification for various chronic diseases …

Biological aging is the main driver of age‐associated chronic diseases. In 2014, the United
States National Institute of Aging (NIA) sponsored a meeting between several investigators …

Aging is a major risk factor to develop neurodegenerative diseases and is associated with
decreased buffering capacity of the proteostasis network. We investigated the significance of …

Skeletal muscle health and function are important determinants of systemic metabolic
homeostasis and organism-wide responses, including disease outcome. While it is well …

Aging is associated with profound alterations in skeletal muscle, including loss of muscle
mass and function, local inflammation, altered mitochondrial physiology, and attenuated …

The aging process is characterized by a progressive decline in the function of most tissues,
representing the main risk factor in the development of a variety of human diseases. Studies …