Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Astrocyte calcium signaling: the third wave

N Bazargani, D Attwell - Nature neuroscience, 2016 - nature.com
The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Dopamine-evoked synaptic regulation in the nucleus accumbens requires astrocyte activity

M Corkrum, A Covelo, J Lines, L Bellocchio… - Neuron, 2020 - cell.com
Dopamine is involved in physiological processes like learning and memory, motor control
and reward, and pathological conditions such as Parkinson's disease and addiction. In …

Gliotransmitters travel in time and space

A Araque, G Carmignoto, PG Haydon, SHR Oliet… - Neuron, 2014 - cell.com
The identification of the presence of active signaling between astrocytes and neurons in a
process termed gliotransmission has caused a paradigm shift in our thinking about brain …

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

J Wahis, A Baudon, F Althammer, D Kerspern… - Nature …, 2021 - nature.com
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural
circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby …

G-protein-coupled receptors in astrocyte–neuron communication

P Kofuji, A Araque - Neuroscience, 2021 - Elsevier
Astrocytes, a major type of glial cell, are known to play key supportive roles in brain function,
contributing to ion and neurotransmitter homeostasis, maintaining the blood–brain barrier …

How does adenosine control neuronal dysfunction and neurodegeneration?

RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Synapse-specific astrocyte gating of amygdala-related behavior

M Martin-Fernandez, S Jamison, LM Robin… - Nature …, 2017 - nature.com
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely
focused on neuronal function and connectivity. Astrocytes functionally interact with neurons …

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

A Covelo, A Araque - elife, 2018 - elifesciences.org
Accumulating evidence indicates that astrocytes are actively involved in brain function by
regulating synaptic activity and plasticity. Different gliotransmitters, such as glutamate, ATP …

Tripartite synapses: astrocytes process and control synaptic information

G Perea, M Navarrete, A Araque - Trends in neurosciences, 2009 - cell.com
The term 'tripartite synapse'refers to a concept in synaptic physiology based on the
demonstration of the existence of bidirectional communication between astrocytes and …