Forging ahead through darkness: PCNA, still the principal conductor at the replication fork

KN Choe, GL Moldovan - Molecular cell, 2017 - cell.com
Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation

M Cardano, C Tribioli, E Prosperi - Current cancer drug targets, 2020 - ingentaconnect.com
Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Q Lei, F Gao, T Liu, W Ren, L Chen, Y Cao… - Science translational …, 2021 - science.org
Stem cell senescence increases alongside the progressive functional declines that
characterize aging. The effects of extracellular vesicles (EVs) are now attracting intense …

LncRNA TUG1 regulates proliferation and apoptosis by regulating miR-148b/IGF2 axis in ox-LDL-stimulated VSMC and HUVEC

X Wu, X Zheng, J Cheng, K Zhang, C Ma - Life sciences, 2020 - Elsevier
Vascular smooth muscle cell (VSMC) accumulation and endothelial cell dysfunction are
associated with pathogenesis of atherosclerosis. Long noncoding RNA taurine up-regulated …

[HTML][HTML] Advances in the fate of rare earth elements, REE, in transitional environments: coasts and estuaries

M Arienzo, L Ferrara, M Trifuoggi, M Toscanesi - Water, 2022 - mdpi.com
The production of rare earth elements, REE, has significantly increased over the past years,
in parallel with the latest advances in nanotechnologies and representing a new group of …

Rare earth elements in marine and terrestrial matrices of Northwestern Italy: Implications for food safety and human health

S Squadrone, P Brizio, C Stella, M Mantia… - Science of the Total …, 2019 - Elsevier
Rare earth elements (REEs) are central in several critical technologies; their use is
constantly increasing as is their release into the environment. For this reason, it is important …

Integrated bilayer microneedle dressing and triboelectric nanogenerator for intelligent management of infected wounds

K Wang, Q Ding, M Qi, W Zhang, Y Hou… - Advanced Functional …, 2024 - Wiley Online Library
The integration of real‐time monitoring and on‐demand treatment has substantial potential
to accelerate wound healing processes. In this context, versatile bilayer microneedles (MNs) …

bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

S Lim, R Khoo, KM Peh, J Teo… - Proceedings of the …, 2020 - National Acad Sciences
Targeted degradation approaches such as proteolysis targeting chimeras (PROTACs) offer
new ways to address disease through tackling challenging targets and with greater potency …

[HTML][HTML] Curcumin and paclitaxel induce cell death in breast cancer cell lines

GM Calaf, R Ponce-Cusi… - Oncology Reports, 2018 - spandidos-publications.com
Breast cancer is one of the major health issues confronting women; however, treatment with
conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a …

Matrix metalloproteinase 9 (MMP9) limits reactive oxygen species (ROS) accumulation and DNA damage in colitis-associated cancer

L Walter, B Canup, A Pujada, TA Bui, B Arbasi… - Cell death & …, 2020 - nature.com
Colitis-associated cancer (CAC) is a subtype of colon cancer that is driven by chronic
inflammation and is prevalent in chronic ulcerative colitis patients. The development of CAC …