Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …

A good portion of the 'protein universe'embodies the 'dark proteome'. The latter comprises
proteins not amenable to experimental structure determination by existing means and …

Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure but exist as
conformational ensembles. Because of their structural plasticity, they can interact with …

Abstract Prostate-associated gene 4 (PAGE4) is an intrinsically disordered protein
implicated in prostate cancer. Thestress-response kinase homeodomain-interacting protein …

It is now well established that intrinsically disordered proteins (IDPs) that constitute a large
part of the proteome across the three kingdoms, play critical roles in several biological …

The past quarter-century may justly be referred to as a period analogous to the “Cambrian
explosion” in the history of proteins. This period is marked by the appearance of the …

Some biological networks exhibit oscillations in their components to convert stimuli to time-
dependent responses. The eukaryotic cell cycle is such a case, being governed by waves of …

In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase
occur through Forkhead transcription factors. These molecules act as controllers of their …

Abstract The Cancer/Testis Antigens (CTAs) are a group of so-called tumor antigens that
exhibit provocative expression patterns in most types of cancer. However, because most …

The classical and idealistic consideration of the protein universe as a set of well-ordered
proteinaceous machines with unique spatial organizations conducting unique biological …