Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

It is from the discovery of leptin and the central nervous system as a regulator of bone
remodeling that the presence of autonomic nerves within the skeleton transitioned from a …

A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from
osteoblasts to adipocytes contributes to age‐and menopause‐associated bone loss and …

Bone homeostasis displays a circadian rhythm with increased resorption during the night
time as compared to day time, a difference that seems—at least partly—to be caused by food …

The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

The neuropeptide Y (NPY) system–comprising of neuropeptide Y, peptide YY, pancreatic
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …

Osteoporosis and sarcopenia are age-related musculoskeletal pathologies that often
develop in parallel. Osteoporosis is characterized by a reduced bone mass and an …

Bariatric surgery remains the most effective treatment for severely obese patients. However,
the potential long‐term effects of bariatric surgical procedures on health, including bone …

The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …