Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Depression is a polygenic and highly complex psychiatric disorder that remains a major
burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) …

The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …

The monoamine hypothesis has been the prevailing hypothesis of depression over the last
several decades. It states that depression is associated with reduced monoamine function …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

Current management of major depression, a common and debilitating disorder with a high
social and personal cost, is far from satisfactory. All available antidepressants act through …

Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in
various species. In vertebrates, melatonin is produced predominantly by the pineal gland …