Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …

Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic
characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important …

CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its
essential role in physiological activities in normal cells and pathological activities in cancer …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

Osteopontin (OPN) was first identified in 1986. The prefix osteo‐means bone; however, OPN
is expressed in other tissues, including liver. The suffix‐pontin means bridge and denotes …