Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in
a variety of medical settings such as wound closure, surgical sealants, regenerative …

In 1971, Gabbiani and co-workers discovered and characterized the “modification of
fibroblasts into cells which are capable of an active spasm”(contraction) in rat wound …

The physiological environment of the intestine is characterized by its variegated
composition, numerous functions and unique dynamic conditions, making it challenging to …

Organoids can shed light on the dynamic interplay between complex tissues and rare cell
types within a controlled microenvironment. Here, we develop gut organoid cocultures with …

Macrophages and dendritic cells are myeloid cells that play critical roles in immune
responses. Macrophages help to maintain homeostasis through tissue regeneration and the …

Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …

Innate immune cells are responsible for eliminating foreign infectious agents and cellular
debris, and their ability to perceive, respond to, and integrate biochemical and mechanical …

Here, we propose an immune-responsive human Microbiota-Intestine axis on-chip as a
platform able to reproduce the architecture and vertical topography of the microbiota with a …

The intestine performs functions central to human health by breaking down food and
absorbing nutrients while maintaining a selective barrier against the intestinal microbiome …

Background & Aims Fibrosis and tissue stiffening are hallmarks of inflammatory bowel
disease (IBD). We have hypothesized that the increased stiffness directly contributes to the …