Oxidative stress has been implicated in the pathogenesis of neurologic and psychiatric
diseases. The brain is particularly vulnerable to oxidative damage due to high oxygen …

Despite years of research, delayed cerebral vasospasm remains the feared complication of
a ruptured intracranial aneurysm. Worldwide effort has led to many promising experimental …

We investigated a possible beneficial role for bilirubin, one of the products of heme
degradation by the cytoprotective enzyme heme oxygenase‐1 in counteracting Escherichia …

Aneurismal subarachnoid haemorrhage (SAH) is a devastating disease that is associated
with significant morbidity and mortality. The mortality is approximately 50%, with 30% of …

Aneurysmal subarachnoid hemorrhage frequently results in complications including
intracranial hypertension, rebleeding and vasospasm. The extravasated blood is …

ContextDelayed cerebral vasospasm causes permanent neurological deficits or death in at
least 15% of patients following otherwise successful treatment for ruptured intracranial …

Colorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing
incidence in younger people. CRC formation is causally linked to various genetic, life-style …

Polyphenolic compounds, such as resveratrol, are naturally present at high concentration in
grape skin, seeds, and red wine. Resveratrol is present in cis and trans isoforms and the …

Bilirubin is the principal product of heme catabolism. High concentrations of the pigment are
neurotoxic, yet slightly elevated levels are beneficial. Being a potent antioxidant, oxidative …

Aneurysmal subarachnoid hemorrhage (SAH) is an acute cerebrovascular emergency
resulting from the rupture of a brain aneurysm. Despite only accounting for 5% of all strokes …