Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis

Y Ren, R Wang, S Weng, H Xu, Y Zhang, S Chen… - Molecular Cancer, 2023 - Springer
The reversible oxidation-reduction homeostasis mechanism functions as a specific signal
transduction system, eliciting related physiological responses. Disruptions to redox …

Protein neddylation and its role in health and diseases

S Zhang, Q Yu, Z Li, Y Zhao, Y Sun - Signal Transduction and Targeted …, 2024 - nature.com
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes

N Hegdekar, C Sarkar, S Bustos, RM Ritzel… - Autophagy, 2023 - Taylor & Francis
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI)
contributes to long-term tissue damage and poor functional outcomes. However, the …

Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers

L Yu, Z Lv, S Li, H Jiang, B Han, X Zheng, Y Liu… - Science of The Total …, 2023 - Elsevier
Arsenic (As) is a well-known pollutant in the environment, whose contamination in
groundwater is a serious threat to animals and humans. Ferroptosis, a form of cell death …

Dinotefuran exposure induces autophagy and apoptosis through oxidative stress in Bombyx mori

Q Lu, S Xu, Z Hao, Y Li, Y Huang, S Ying, W Jing… - Journal of Hazardous …, 2023 - Elsevier
As a third-generation neonicotinoid insecticide, dinotefuran is extensively used in
agriculture, and its residue in the environment has potential effects on nontarget organisms …

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity

Q Li, X Zhong, W Yao, J Yu, C Wang, Z Li, S Lai… - Journal of Biological …, 2022 - ASBMB
Despite the enormous successes of anti-PD-1/PD-L1 immunotherapy in multiple other
cancer types, the overall response rates of breast cancer remain suboptimal. Therefore …

Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells

J Li, Y Sun, X Zhao, Y Ma, Y Xie, S Liu, B Hui… - Cell Death & …, 2023 - nature.com
Radiotherapy is the standard adjuvant treatment for glioma patients; however, the efficacy is
limited by radioresistance. The function of Interleukin-1 receptor associated kinase 1 …

The induction of endothelial autophagy and its role in the development of atherosclerosis

Y Hua, J Zhang, Q Liu, J Su, Y Zhao… - Frontiers in …, 2022 - frontiersin.org
Increasing attention is now being paid to the important role played by autophagic flux in
maintaining normal blood vessel walls. Endothelial cell dysfunction initiates the …

Sonoactivated Z‐Scheme Heterojunction for Enhanced Sonodynamic Mitophagy Inhibition and Triple Negative Breast Cancer Treatment

Y Zheng, T Zhang, M Chang, L Xia, L Chen… - Advanced …, 2024 - Wiley Online Library
Sonodynamic therapy (SDT) has emerged as a potent therapeutic modality to generate
intratumoral toxic reactive oxygen species (ROS) in combating refractory triple‐negative …

Mitophagy in atherosclerosis: from mechanism to therapy

Y Zhang, J Weng, L Huan, S Sheng, F Xu - Frontiers in Immunology, 2023 - frontiersin.org
Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized
mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways …