Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

Oncolytic viruses (OVs) demonstrate the ability to replicate selectively in cancer cells,
resulting in antitumor effects by a variety of mechanisms, including direct cell lysis and …

Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter
in molecular thyroidology with the characterization of NIS as one of the most powerful …

Current standard treatments of cancer can prolong survival of many cancer patients but
usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic …

Despite advances in technology, the formidable challenge of treating cancer, especially if
advanced, still remains with no significant improvement in survival rates, even with the most …

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and
current treatments are ineffective in increasing patients' survival. Thus, the development of …

Vascular endothelial growth factor (VEGF) expression is higher in triple-negative breast
cancers (TNBC) compared to other subtypes and is reported to predict incidence of distant …

Introduction: Oncolytic viruses are experimental cancer therapies being translated to the
clinic. They are unique in their ability to amplify within the body, therefore requiring careful …

Background Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors
for which no effective therapies are currently available. Oncolytic Newcastle disease virus …

The incidence of thyroid cancers has been steadily increasing worldwide over the past few
decades. Although five-year survival rates for differentiated thyroid cancers are upwards of …