Peptide design and self-assembly into targeted nanostructure and functional materials

NJ Sinha, MG Langenstein, DJ Pochan… - Chemical …, 2021 - ACS Publications
Peptides have been extensively utilized to construct nanomaterials that display targeted
structure through hierarchical assembly. The self-assembly of both rationally designed …

Nanoarchitectonics beyond self‐assembly: challenges to create bio‐like hierarchic organization

K Ariga, X Jia, J Song, JP Hill… - Angewandte Chemie …, 2020 - Wiley Online Library
Incorporation of non‐equilibrium actions in the sequence of self‐assembly processes would
be an effective means to establish bio‐like high functionality hierarchical assemblies. As a …

Towards glycan foldamers and programmable assemblies

S Djalali, N Yadav, M Delbianco - Nature Reviews Materials, 2024 - nature.com
Natural biopolymers have inspired the development of synthetic analogues that can adopt
defined conformations and assemble into 3D architectures. These compounds are mainly …

Recent advances in collagen mimetic peptide structure and design

SAH Hulgan, JD Hartgerink - Biomacromolecules, 2022 - ACS Publications
Collagen mimetic peptides (CMPs) fold into a polyproline type II triple helix, allowing the
study of the structure and function (or misfunction) of the collagen family of proteins. This …

Molecular, local, and network-level basis for the enhanced stiffness of hydrogel networks formed from coassembled racemic peptides: predictions from Pauling and …

K Nagy-Smith, PJ Beltramo, E Moore, R Tycko… - ACS central …, 2017 - ACS Publications
Hydrogels prepared from self-assembling peptides are promising materials for medical
applications, and using both l-and d-peptide isomers in a gel's formulation provides an …

Advances in the design and higher-order assembly of collagen mimetic peptides for regenerative medicine

K Strauss, J Chmielewski - Current opinion in biotechnology, 2017 - Elsevier
Highlights•Collagen mimetic peptide biomaterials are superior to natural collagen in many
ways.•Strategic sequence design allows for reliable higher-order self-assembly.•Varying pH …

Shape-shifting peptide nanomaterials: surface asymmetry enables pH-dependent formation and interconversion of collagen tubes and sheets

AD Merg, G Touponse, E Genderen… - Journal of the …, 2020 - ACS Publications
The fabrication of dynamic, transformable biomaterials that respond to environmental cues
represents a significant step forward in the development of synthetic materials that rival their …

Peptide Tectonics: Encoded Structural Complementarity Dictates Programmable Self‐Assembly

S Lou, X Wang, Z Yu, L Shi - Advanced Science, 2019 - Wiley Online Library
Programmable self‐assembly of peptides into well‐defined nanostructures represents one
promising approach for bioinspired and biomimetic synthesis of artificial complex systems …

Seeded heteroepitaxial growth of crystallizable collagen triple helices: engineering multifunctional two-dimensional core–shell nanostructures

AD Merg, E van Genderen, A Bazrafshan… - Journal of the …, 2019 - ACS Publications
Engineering free-standing 2D nanomaterials with compositional, spatial, and functional
control across size regimes from the nano-to mesoscale represents a significant challenge …

Structurally ordered nanowire formation from co-assembly of DNA origami and collagen-mimetic peptides

T Jiang, TA Meyer, C Modlin, X Zuo… - Journal of the …, 2017 - ACS Publications
We describe the co-assembly of two different building units: collagen-mimetic peptides and
DNA origami. Two peptides CP++ and sCP++ are designed with a sequence comprising a …