Global populations are undergoing a major epidemiological transition in which the burden of
atherosclerotic cardiovascular diseases is shifting rapidly from high-income to low-income …

The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

Respiratory infections and diseases are among the leading causes of death worldwide, and
effective treatments probably require manipulating the inflammatory response to pathogenic …

Abstract Interleukin-17 (IL-17), IL-21, IL-22 and IL-23 can be grouped as T helper 17 (Th17)-
related cytokines because they are either produced by Th17/Th22 cells or involved in their …

The burden of tuberculosis and cardiovascular disease (CVD) is enormous worldwide. CVD
rates are rapidly increasing in low-and middle-income countries. Public health programs …

Approximately 2 billion people are infected with Mycobacterium tuberculosis (Mtb), resulting
in 1.4 million deaths every year. Among Mtb-infected individuals, clinical isolates belonging …

CD 4+ T cells maintain cancer surveillance and immune tolerance. Chronic inflammation
has been proposed as a driver of clonal evolution in myeloproliferative neoplasms (MPN) …

The classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1
responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory …

Background Tuberculosis has been associated with an increased risk of cardiovascular
disease (CVD), including acute myocardial infarction (AMI). We investigated whether latent …

T helper 22 (Th22) cells, a newly defined CD4+ T-cell lineage, are characterized by their
distinct cytokine profile, which primarily consists of IL-13, IL-22 and TNF-α. Th22 cells …