The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM
phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the …

In addition to hyperresponsiveness in asthma, airway smooth muscle (ASM) also manifests
an inflammatory phenotype characterized by augmented expression of mediators that …

Asthma is characterized by airway inflammation, mucus secretion, remodeling and
hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of …

Defining mechanisms by which differentiated, contractile smooth muscle cells become
proliferative and secretory in response to mechanical and environmental stress is crucial for …

Statins inhibit 3-hydroxy-3-methyl-glutarylcoenzyme CoA (HMG-CoA) reductase, the
proximal enzyme for cholesterol biosynthesis. They exhibit pleiotropic effects and are linked …

Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G
protein-coupled receptors causes airway hyperresponsiveness in asthma. Activation of Gq …

Airway smooth muscle (ASM) cell dysfunction is an important component of several
obstructive pulmonary diseases, particularly asthma. External stimuli such as allergens …

Clinical asthma is characterized by reversible airway obstruction which is commonly due to
an exaggerated airway narrowing referred to as airway hyperresponsiveness (AHR) …

Asthma pathobiology includes oxidative stress that modifies cell membranes and
extracellular phospholipids. Oxidized phosphatidylcholines (OxPCs) in lung lavage from …

Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic)
and caspase-independent (necrosis-like) cell death in different cells. We used the murine …