Tissue regeneration by stem cells is driven by the paracrine activity of shedding vesicles and
exosomes, which deliver specific cargoes to the recipient cells. Proteins, RNA, cytokines and …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Both mitochondria and lysosomes are essential for maintaining cellular homeostasis, and
dysfunction of both organelles has been observed in multiple diseases,,,. Mitochondria are …

Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …

Tethering factors have been shown to interact with Rabs and SNAREs and, more recently,
with coat proteins. Coat proteins are required for cargo selection and membrane …

The fusion of transport vesicles with their target membranes is fundamental for intracellular
membrane trafficking and diverse physiological processes and is driven by the assembly of …

Secretory proteins are transported to the Golgi complex in vesicles that bud from the
endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for …

The exocyst complex is an evolutionarily conserved multisubunit protein complex implicated
in tethering secretory vesicles to the plasma membrane. Originally identified two decades …