Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Immunoglobulin germline gene variation and its impact on human disease
Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
The spatial distribution of lymphocyte clones within tissues is critical to their development,
selection, and expansion. We have developed spatial transcriptomics of variable, diversity …
selection, and expansion. We have developed spatial transcriptomics of variable, diversity …
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
P Pushparaj, A Nicoletto, DJ Sheward, H Das… - Immunity, 2023 - cell.com
The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …
The evolutionary and functional significance of germline immunoglobulin gene variation
The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
[HTML][HTML] The role of metadata in reproducible computational research
Reproducible computational research (RCR) is the keystone of the scientific method for in
silico analyses, packaging the transformation of raw data to published results. In addition to …
silico analyses, packaging the transformation of raw data to published results. In addition to …
Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
M Corcoran, M Chernyshev, M Mandolesi, S Narang… - Immunity, 2023 - cell.com
Human T cell receptors (TCRs) are critical for mediating immune responses to pathogens
and tumors and regulating self-antigen recognition. Yet, variations in the genes encoding …
and tumors and regulating self-antigen recognition. Yet, variations in the genes encoding …
Improving generalization of machine learning-identified biomarkers using causal modelling with examples from immune receptor diagnostics
Abstract Machine learning is increasingly used to discover diagnostic and prognostic
biomarkers from high-dimensional molecular data. However, a variety of factors related to …
biomarkers from high-dimensional molecular data. However, a variety of factors related to …
T cell receptor beta germline variability is revealed by inference from repertoire data
Background T and B cell receptor (TCR, BCR) repertoires constitute the foundation of
adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a …
adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a …