Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

Simple Summary Skeletal muscle mass is an important economic trait, and muscle
development and growth is a crucial factor to supply enough meat for human consumption …

Maintenance of skeletal muscle mass is regulated by the balance between anabolic and
catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved …

Life expectancy is increasing worldwide, with a resultant increase in the elderly population.
Aging is characterized by the progressive loss of skeletal muscle mass and strength–a …

Skeletal muscle mass increases during postnatal development through a process of
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …

Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a
cascade of intracellular components that mediate its effects, plays a major role in the …