Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

While modulatory effects of gut microbes on neurological phenotypes have been reported,
the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …

Alzheimer׳ s disease (AD) is the most common cause of dementia in North America.
Growing evidence supports the concept that AD is a metabolic disease mediated by …

The hippocampus is an important part of the limbic system in the human brain that has
essential roles in spatial navigation and the consolidation of information from short-term …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

Stroke, resulting from limited blood flow to the brain, is one of the most important causes of
morbidity and mortality worldwide. Stroke is classified as ischemic, due to lack of blood flow …