Von Willebrand's disease is an inherited bleeding disorder with a prevalence as high as 1 to
2 percent in the general population, according to screening studies. However, its prevalence …

Von Willebrand disease is a common autosomal inherited bleeding disorder caused by
quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that …

von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder
affecting both males and females, causing mucous membrane and skin bleeding symptoms …

In persons with hemophilia, life expectancy is now approaching that of the general male
population, at least in countries that can afford regular replacement therapy with coagulation …

Abstract von Willebrand factor (VWF) is a large multimeric adhesive glycoprotein with
complex roles in thrombosis and hemostasis. Abnormalities in VWF give rise to a variety of …

BACKGROUND: Von Willebrand's disease (VWD) is an autosomally inherited bleeding
disorder caused by a deficiency or abnormality of von Willebrand factor (VWF). VWF is a …

Safety and pharmacokinetics (PK) of recombinant von Willebrand factor (rVWF) combined at
a fixed ratio with recombinant factor VIII (rFVIII) were investigated in 32 subjects with type 3 …

Along with haemophilia A and B, von Willebrand disease (VWD) and rare bleeding
disorders (RBDs) cover all inherited bleeding disorders of coagulation. Bleeding tendency …

Given the wide heterogeneity of phenotypes and of the underlying pathophysiological
mechanisms associated with the disorder, pregnancy and delivery in von Willebrand …

The bleeding patterns of severe von Willebrand's disease (VWD) adversely affect quality of
life, and may be life threatening. There is a presumed role for prophylaxis with VWF …