Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Its
virulence is largely due to its polysaccharide capsule, which shields it from the host immune …

Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and
septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To …

Abstract Hydrogen peroxide (H2O2) has a major function in host-microbial interactions.
Although most studies have focused on the endogenous H2O2 produced by immune cells to …

DNA methylation is an important epigenetic mechanism for phenotypic diversification in all
forms of life. We previously described remarkable cell-to-cell heterogeneity in epigenetic …

Community‐acquired pneumonia (CAP) remains a leading cause of morbidity and mortality
among the infectious diseases. Despite the implementation of national pneumococcal …

Streptococcus pneumoniae is a commensal bacterium and invasive pathogen that causes
millions of deaths worldwide. The pneumococcal vaccine offers limited protection, and the …

The genus Streptococcus contains 104 recognized species, many of which are associated
with human or animal hosts. A globally prevalent human pathogen in this group is …

The pneumococcus is one of the most prodigious producers of hydrogen peroxide amongst
bacterial pathogens. Hydrogen peroxide production by the pneumococcus has been …

Streptococcus pneumoniae is a fermentative microorganism and causes serious diseases in
humans, including otitis media, bacteremia, meningitis, and pneumonia. However, the …

Many commensal oral streptococci generate H2O2 via pyruvate oxidase (SpxB) to inhibit the
growth of competing bacteria like Streptococcus mutans, a major cariogenic species. In …