Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual
uncovering of substrate mechanical characteristics that can affect cell-matrix interactions …

This review explores state-of-the-art and new perspectives description of scaffold-based
strategies utilized in in-suit bone tissue engineering. The bone defects caused by severe …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

Electrospun nanofibers have been extensively explored as a class of scaffolding materials
for tissue regeneration, because of their unique capability to mimic some features and …

Successful tissue regeneration strategies focus on the use of novel biomaterials, structures,
and a variety of cues to control cell behavior and promote regeneration. Studies discovered …

Accumulating evidence indicates that the physicochemical properties of biomaterials exert
profound influences on stem cell fate decisions. However, matrix-based regulation selected …

Annulus fibrosus (AF) tissue engineering has attracted increasing attention as a promising
therapy for degenerative disc disease (DDD). However, regeneration of AF still faces many …

Abstract Three-dimensional (3D) scaffolds as artificial ECMs have been extensively studied
to mimic the critical features of natural ECMs. To develop more clinically relevant 3D …

In response to chemical stimuli from cancer cells, mesenchymal stem cells (MSC) can
differentiate into cancer-associated fibroblasts (CAF) and promote tumor progression. How …