Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Mitochondrial dysfunction is now recognized as a contributing factor to neurodegenerative
diseases, including Alzheimer's disease (AD). Mitochondria are signaling organelles with a …

Translating human genetic findings (genome-wide association studies [GWAS]) to
pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease …

Neurodegeneration, a process of irreversible neuronal damage, is characterized by a
damaged neuronal structure and function. The interplay between various proteins maintains …

MAP/microtubule affinity‐regulating kinase 4 (MARK4) is a member of serine/threonine
kinase family and considered an attractive drug target for many diseases. Screening of …

Utilization of carbon dioxide as a C1 synthon is highly attractive for the synthesis of valuable
chemicals. However, activation of CO2 is highly challenging, owing to its thermodynamic …

Cyclin-dependent kinase 6 (CDK6) is a potential drug target that plays an important role in
the progression of different types of cancers. We performed in silico and in vitro screening of …

Identifying novel molecules as potential kinase inhibitors are gaining significant attention
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …

Irisin is a clinically significant protein playing a valuable role in regulating various diseases.
Irisin attenuates synaptic and memory dysfunction, highlighting its importance in Alzheimer's …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
caused by multi-factors and characterized by two histopathological hallmarks: amyloid-β …