Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical …

Amyotrophic lateral sclerosis (ALS) is a grievous neurodegenerative disease whose survival
is limited to only a few years. In spite of intensive research to discover the underlying …

Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of
amyotrophic lateral sclerosis and frontotemporal dementia and correlates with …

The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like
domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon …

Abstract TAR DNA binding protein 43 (TDP-43) is closely related to the pathogenesis of
amyotrophic lateral sclerosis (ALS) and translocates to stress granules (SGs). The role of …

Cellular stress pathways that inhibit translation initiation lead to transient formation of
cytoplasmic RNA/protein complexes known as stress granules. Many of the proteins found …

Cytoplasmic ribonucleoproteins called stress granules (SGs) are considered as one of the
main cellular solutions against stress. Their temporary presence ends with stress relief. Any …

The secretory pathway is an intracellular highway for the vesicular transport of newly
synthesized proteins that spans the endoplasmic reticulum (ER), Golgi, lysosomes and the …

The aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) into fibrillary deposits is
implicated in amyotrophic lateral sclerosis (ALS), and some hereditary mutations localized in …

While unbiased proteomics of human cerebrospinal fluid (CSF) has been used successfully
to identify biomarkers of amyotrophic lateral sclerosis (ALS), high‐abundance proteins mask …