Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …

Pluripotent stem cell (PSC)-derived human brain organoids enable the study of human brain
development in vitro. Typically, the fate of PSCs is guided into subsequent specification …

Huntington's disease (HD) causes selective degeneration of striatal and cortical neurons,
resulting in cell mosaicism of coexisting still functional and dysfunctional cells. The impact of …

Organoids are systems derived from pluripotent stem cells at the interface between
traditional monolayer cultures and in vivo animal models. The structural and functional …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

Brain organoid methods are complicated by multiple rosette structures and morphological
variability. We have developed a human brain organoid technique that generates self …

EP400 encodes a core catalytic ATPase subunit of ATP-dependent chromatin remodeling
complexes. The gene-disease association of EP400 is undetermined. In this study, we …

Neural tube defects (NTDs), including anencephaly and spina bifida, are common major
malformations of fetal development resulting from incomplete closure of the neural tube …

The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation
causes a syndromic form of autism spectrum disorder (ASD): Phelan-McDermid Syndrome …