After it was discovered approximately 40 years ago, carbohydrate antigen 125 (CA125)
became the most widely used and concerning biomarker in ovarian cancer screening …

The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …

Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in
tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe …

Simple Summary Ovarian high-grade serous carcinoma (HGSC) has a 5-year survival rate
of less than 50%, making it one of the most lethal gynecological cancers for women in the …

Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer
pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa, Lewisb …

Background While the underlying causes of cancer are genetic modifications, changes in
cellular states mediate cancer development. Tumor cells display markedly changed …

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …

MUC16 (the cancer antigen CA125) is the most commonly used serum biomarker in
epithelial ovarian cancer, with increasing levels reflecting disease progression. It is a …