Neurodegenerative disorders represent a major and growing healthcare challenge globally.
Among the numerous molecular pathways implicated in their pathogenesis, calpain …

This review was written in memory of our late friend, Dr. Hiroyuki Sorimachi, who, following
the steps of his mentor Koichi Suzuki, a pioneer in calpain research, has made tremendous …

Drugs targeting host proteins can act prophylactically to reduce viral burden early in disease
and limit morbidity, even with antivirals and vaccination. Transmembrane serine protease 2 …

Ophthalmic neurodegenerative diseases encompass a wide array of molecular pathologies
unified by calpain dysregulation. Calpains are calcium-dependent proteases that perpetuate …

Abstract Calpain, a Ca 2+-dependent cysteine protease, plays a significant role in gene
expression, signal transduction, and apoptosis. Mutations in human calpain-5 cause …

Objective To elucidate molecular risk factors for posterior segment uveitis using a functional
genomics approach. Design Genetic association cohort study. Methods S etting: Single …

The enzymatic characteristics of the ubiquitous calpain 5 (CAPN5) remain undescribed
despite its high expression in the central nervous system and links to eye development and …

Intracellular calcium dynamics is key to regulating various physiological events. Myotube
formation by myoblast fusion is controlled by the release of Ca 2+ from the endoplasmic …

Rare diseases are an emerging global health priority. Although individually rare, the
prevalence of rare" orphan" diseases is high, affecting approximately 300 million people …

Amyloid plaques are considered to be the pathological hallmark of Alzheimer's disease
(AD). Neuroinflammation further aggravates the pathogenesis of Alzheimer's disease …