Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

Abstract Purpose of Review The periosteum, the outer layer of bone, is a major source of
skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on …

Mechanical force regulates bone density, modeling, and homeostasis. Substantial periosteal
bone formation is generated by external mechanical stimuli, yet its mechanism is poorly …

The primary cilium is a nonmotile microtubule-based organelle in most vertebrate cell types.
The primary cilium plays a critical role in tissue development and homeostasis by sensing …

Primary cilia are vital signaling organelles that extend from most types of cells, including
neurons and glia. These structures are essential for development of many tissues and …

Bone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells
with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and …

Bone marrow mesenchymal stem cells (BMSCs) are multi-potent cell populations and are
capable of maintaining bone and body homeostasis. The stemness and potential …

Gravity determines shape of body tissue and affects the functions of life, both in plants and
animals. The cellular response to gravity is an active process of mechanotransduction …