The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by
the development of several experimental anticancer‐and anti‐ischaemia (stroke or …

Mammalian oocytes are long-lived cells in the human body. They initiate meiosis already in
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …

Grade of membership models, also known as “admixture models”,“topic models” or “Latent
Dirichlet Allocation”, are a generalization of cluster models that allow each sample to have …

BACKGROUND The first week of human embryonic development comprises a series of
events that change highly specialized germ cells into undifferentiated human embryonic …

The existence of the bcl-2 (B-cell lymphoma-2) gene was reported nearly 30years ago. Yet,
Bcl-2 family group of proteins still surprises us with their structural and functional diversity …

Social and environmental factors render premature ovarian failure (POF) as a major cause
of decline or loss of female fertility. The natural pregnancy rate of patients with POF is only …

Abstract In women, up to 99.9% of the oocyte stockpile formed during fetal life is decimated
by apoptosis. Apoptotic features are also detected in human preimplantation embryos both …

Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many
healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many …

Abstract B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated
apoptosis. We have investigated the structure and function of the least characterized Bcl-2 …

Stored maternal factors in oocytes regulate oocyte differentiation into embryos during early
embryonic development. Before zygotic gene activation (ZGA), these early embryos are …