Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …

Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms
that counteract the effect of chemotherapeutic compounds, leading to relapse and the …

The development of effective treatments for cancers requires investigations for a more
detailed and comprehensive understanding of the basic cellular mechanisms involved in …

Evasion of apoptosis is considered to be one of the hallmarks of human cancers. This cell
death modality is executed by caspases and several upstream regulatory factors, which …

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and
pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies …

Breast cancer has an extremely high incidence in women, and its morbidity and mortality
rank first among female tumors. With the increasing development of medicine today, the …

Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …

Tissue development and homeostasis are regulated by opposing pro-survival and pro-death
signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that …

The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or
TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The …