The 26S proteasome is involved in degrading and regulating the majority of proteins in
eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this …

Abstract p97 (also known as Cdc48, Ter94, and VCP) is an essential, abundant and highly
conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes. Even though …

Abstract The AAA+ Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-
dependent cell signaling, degradation, and quality control pathways. Central to these broad …

Neddylation is a post-translational protein modification that conjugates a ubiquitin-like
protein NEDD8 to target proteins. Similar to ubiquitination, neddylation is mediated by a …

Genomic DNA is damaged at an extremely high frequency by both endogenous and
environmental factors. An improper response to DNA damage can lead to genome …

Glioblastoma (GBM) presents significant challenges due to its invasive nature and genetic
heterogeneity. In this study, we investigated the impact of Small VCP/P97-Interacting Protein …

Summary The type II AAA ATPase p97 interacts with a large number of cofactors that
regulate its function by recruiting it to different cellular pathways. Most of the cofactors …

Histone lysine demethylases (KDMs) play a vital role in regulating chromatin dynamics and
transcription. KDM proteins are given modular activities by its sequence motifs with obvious …

Expansion of polyglutamine (polyQ) tract may cause protein misfolding and aggregation that
lead to cytotoxicity and neurodegeneration, but the underlying mechanism remains to be …

The ubiquitin-proteasome system (UPS) degrades soluble proteins and small aggregates,
whereas macroautophagy (autophagy herein) eliminates larger protein aggregates, tangles …