An update on poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors: opportunities and challenges in cancer therapy
YQ Wang, PY Wang, YT Wang, GF Yang… - Journal of medicinal …, 2016 - ACS Publications
Poly (ADP-ribose) polymerase-1 (PARP-1) is a critical DNA repair enzyme in the base
excision repair pathway. Inhibitors of this enzyme comprise a new type of anticancer drug …
excision repair pathway. Inhibitors of this enzyme comprise a new type of anticancer drug …
A road map to personalizing targeted cancer therapies using synthetic lethality
S Parameswaran, D Kundapur, FS Vizeacoumar… - Trends in Cancer, 2019 - cell.com
Targeted therapies rely on the genetic and epigenetic status of the tumor cells and are seen
as the most promising approach to treat cancer today. However, current targeted therapies …
as the most promising approach to treat cancer today. However, current targeted therapies …
[HTML][HTML] E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling
S McGonigle, Z Chen, J Wu, P Chang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Inhibition of Poly (ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and
early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical …
early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical …
PARP1 inhibition augments UVB-mediated mitochondrial changes—implications for UV-induced DNA repair and photocarcinogenesis
Keratinocytes provide the first line of defense of the human body against carcinogenic
ultraviolet (UV) radiation. Acute and chronic UVB-mediated cellular responses were widely …
ultraviolet (UV) radiation. Acute and chronic UVB-mediated cellular responses were widely …
PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions
JA Ledermann, F El-Khouly - British journal of cancer, 2015 - nature.com
Ovarian cancer is the fifth leading cause of female cancer deaths in the Western world.
Significant progress has been made in the treatment of patients with ovarian cancer …
Significant progress has been made in the treatment of patients with ovarian cancer …
Az UVB-indukált akut DNS károsodás szerepe a mitokondriumok működésének szabályozásában
C Hegedűs - 2021 - search.proquest.com
Munkánk során igazoltuk az UVB irradiációt követő akut DNS károsodás és a
mitokondriumok megváltozott morfológiája, valamint metabolizmusa közötti kapcsolatot. A …
mitokondriumok megváltozott morfológiája, valamint metabolizmusa közötti kapcsolatot. A …