Aniline (in the form of its hydrochloride) has been shown to induce a rather rare spectrum of
tumors in the spleen of Fischer 344 rats. The dose levels necessary for this carcinogenic …

We review the experimental evidence for various shapes of dose-response relationships for
carcinogens and summarize those experiments that give the most information on relatively …

Risk assessment is presented as a way of examining risks so that they may be better
avoided, reduced, or otherwise managed. Risk implies uncertainty, so that risk assessment …

We have recently developed an alkaline elution/rat hepatocyte assay to sensitively measure
DNA single-strand breaks induced by xenobiotics in non-radiolabeled rat hepatocytes. Here …

This is the second of two reports from the International Workshops on Genotoxicity Testing
(IWGT) Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment …

Abstract p-Chloroaniline (PCA), a dye intermediate, was evaluated for potential long-term
toxicity and carcinogenicity. Groups of 50 F344/N rats of each sex were given by gavage …

DNA strand breaks induced in human CCRF-CEM cells by electrophilic chemicals
(carcinogens/mutagens) can be readily quantitated via a facile alkaline unwinding assay …

Determining the carcinogenicity and carcinogenic potency of new chemicals is both a labor-
intensive and time-consuming process. In order to expedite the screening process, there is a …

The relationship between the minimum TD50 (i‐e., the TD50 measured at the most sensitive
site) and the maximum dose administered (maxD) in rodent carcinogenicity bioassays was …

An experimental approach was taken to the question of dose-response curves for chemical
carcinogenesis. DNA damage in female rat liver was chosen as the experimental parameter …