Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the
chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types …

Macrophages are distributed in tissues throughout the body and contribute to both
homeostasis and disease. Recently, it has become evident that most adult tissue …

Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These
proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA …

The CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into
inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression …

Monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most extensively
studied CC chemokine, and the amount of studies on its role in the etiologies of obesity-and …

Toll-like receptors (TLRs) recognize microbial components, and evoke inflammation and
immune responses,,. TLR stimulation activates complex gene expression networks that …

Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the
excessive generation or accumulation of free radicals or their oxidation products. Free …

Myocardial infarction (MI) is the most common cause of cardiac injury, and subsequent
reperfusion further enhances the activation of innate and adaptive immune responses and …