A novel imaging method (FIM-ID) reveals that myofibrillogenesis plays a major role in the mechanically induced growth of skeletal muscle

KW Jorgenson, JE Hibbert, RKA Sayed, AN Lange… - Elife, 2024 - elifesciences.org
An increase in mechanical loading, such as that which occurs during resistance exercise,
induces radial growth of muscle fibers (ie an increase in cross-sectional area). Muscle fibers …

Transcriptomic and Phenotypic Analysis of CRISPR/Cas9-Mediated gluk2 Knockout in Zebrafish

Q Yan, W Li, X Gong, R Hu, L Chen - Genes, 2022 - mdpi.com
As a subtype of kainite receptors (KARs), GluK2 plays a role in the perception of cold in the
periphery sensory neuron. However, the molecular mechanism for gluk2 on the cold stress …

Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment

JL Braun, VA Fajardo - npj Microgravity, 2024 - nature.com
Spending time in a microgravity environment is known to cause significant skeletal muscle
atrophy and weakness via muscle unloading, which can be partly attributed to Ca2+ …

Identifying the Ultrastructural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle

KW Jorgenson - 2024 - search.proquest.com
The preservation of skeletal muscle mass is crucial for maintaining overall health and well-
being. Mechanical loading, particularly through resistance exercise, plays a key role in …

Loss of neuronatin increases susceptibility of SERCA to thermal inactivation

M Barfoot, VA Fajardo, JL Braun - bioRxiv, 2023 - biorxiv.org
Phospholamban and sarcolipin are two key regulators of the sarco (endo) plasmic reticulum
Ca2+-ATPase (SERCA) that have been shown to protect SERCA from thermal inactivation in …