An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Unilateral ureteral obstruction is a popular experimental model of renal injury. However, the
study of the kidney response to urinary tract obstruction is only one of several advantages of …

Local inflammation is thought to contribute to the progression of diabetic nephropathy. The
vitamin D receptor (VDR) activator paricalcitol has an antiproteinuric effect in human diabetic …

Introduction The current therapeutic armamentarium to prevent chronic kidney disease
(CKD) progression is limited to the control of blood pressure and in diabetic patients, the …

Recent studies have revealed the connection between amino acid chirality and diseases.
We have previously reported that the gut microbiota produces various d-amino acids in a …

Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease
(NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid …

BACKGROUND: Vascular calcification (VC) is a highly prevalent complication of chronic
kidney disease (CKD) and is associated with the higher morbidity-mortality of patients with …

Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney
disease. Alpha-(α)-synuclein (SNCA) is an actin-binding neuronal protein with various …

Introduction: NMDA receptor (NMDAR) is an ionotropic glutamate receptor with a high
permeability to calcium and a unique feature of controlling numerous calcium-dependent …

Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential
role in the initiation and progression of atherosclerosis. Vitamin D has cardioprotective …