Machine learning in bioprocess development: from promise to practice

LM Helleckes, J Hemmerich, W Wiechert… - Trends in …, 2023 - cell.com
Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess
development provides large amounts of heterogeneous experimental data, containing …

Quality by Design for enabling RNA platform production processes

S Daniel, Z Kis, C Kontoravdi, N Shah - Trends in biotechnology, 2022 - cell.com
RNA-based products have emerged as one of the most promising and strategic
technologies for global vaccination, infectious disease control, and future therapy …

Lignocellulosic biomass in circular economy: A techno-transition in carbon neutrality towards sustainable energy production

MA Bhat, MA Bhat, S Jan, AA Shah, AT Jan - Biomass and Bioenergy, 2024 - Elsevier
The ongoing energy crisis and global warming threat represent major challenges of the
century. Our dependence on conventional fuels has reached to a critical level where …

Simple plant‐based production and purification of the assembled human ferritin heavy chain as a nanocarrier for tumor‐targeted drug delivery and bioimaging in …

M Knödler, P Opdensteinen… - Biotechnology and …, 2023 - Wiley Online Library
Nanoparticles are used as carriers for the delivery of drugs and imaging agents. Proteins are
safer than synthetic nanocarriers due to their greater biocompatibility and the absence of …

Recent advances and future directions in downstream processing of therapeutic antibodies

A Matte - International Journal of Molecular Sciences, 2022 - mdpi.com
Despite the advent of many new therapies, therapeutic monoclonal antibodies remain a
prominent biologics product, with a market value of billions of dollars annually. A variety of …

Application of near-infrared spectroscopy for monitoring and/or control of composting processes

T Sokač Cvetnić, K Krog, M Benković, T Jurina… - Applied Sciences, 2023 - mdpi.com
The implementation of a suitable and ecologically friendly solid waste management plan is
accepted as an essential need. Given that organic matter constitutes the majority of solid …

Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell‐derived extracellular vesicles in stirred‐tank bioreactors

MHG Costa, MS Costa, B Painho… - Biotechnology and …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) act as
signaling mediators of cellular responses. However, despite representing a promising …

[HTML][HTML] An integrated perspective on measuring cytokines to inform CAR-T bioprocessing

HK Williamson, PM Mendes - Biotechnology Advances, 2024 - Elsevier
Chimeric antigen receptor (CAR)-T cells are emerging as a generation-defining therapeutic
however their manufacture remains a major barrier to meeting increased market demand …

Insights on the extraction and analysis of phenolic compounds from citrus fruits: green perspectives and current status

VL Sanches, LM de Souza Mesquita… - Critical Reviews in …, 2024 - Taylor & Francis
Citrus fruits (CF) are highly consumed worldwide, fresh, processed, or prepared as juices
and pies. To illustrate the high economic importance of CF, the global production of these …

rAAV manufacturing: the challenges of soft sensing during upstream processing

CF Iglesias Jr, M Ristovski, M Bolic, M Cuperlovic-Culf - Bioengineering, 2023 - mdpi.com
Recombinant adeno-associated virus (rAAV) is the most effective viral vector technology for
directly translating the genomic revolution into medicinal therapies. However, the …